The negative control group3 days after the last administration20348.1 ± 95.72.04 ± 0.170.62 ± 0.151.10 ± 0.280.32 ± 0.0310.05 ± 2.592.92 ± 0.352.31 ± 0.580.67 ± 0.060.07 ± 0.020.02 ± 0.010.47 ± 0.150.14 ± 0.03The solvent control group376.6 ± 98.02.05 ± 0.140.58 ± 0.141.21 ± 0.280.33 ± 0.0411.55 ± 3.453.07 ± 0.382.57 ± 0.700.68 ± 0.060.16 ± 0.330.05 ± 0.120.50 ± 0.120.14 ± 0.04The low-dose vaccine group369.2 ± 97.32.04 ± 0.210.58 ± 0.121.18 ± 0.290.32 ± 0.0410.94 ± 3.472.96 ± 0.382.51 ± 0.760.68 ± 0.070.07 ± 0.020.02 ± 0.010.49 ± 0.120.14 ± 0.03The high-dose vaccine group364.0 ± 97.42.03 ± 0.170.59 ± 0.141.19 ± 0.270.33 ± 0.0310.97 ± 2.883.03 ± 0.282.40 ± 0.630.66 ± 0.070.07 ± 0.010.02 ± 0.010.47 ± 0.120.13 ± 0.03GroupTest timeNumber of animalsSpleenLungTestisEpididymisOvaryUterusAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weight(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)The negative control group3 days after the last administration200.70 ± 0.170.21 ± 0.041.67 ± 0.330.50 ± 0.093.29 ± 0.290.12 ± 0.261.54 ± 0.340.06 ± 0.140.10 ± 0.030.04 ± 0.010.61 ± 0.120.24 ± 0.05The solvent control group0.74 ± 0.170.20 ± 0.031.77 ± 0.350.48 ± 0.053.28 ± 0.400.70 ± 0.111.41 ± 0.290.30 ± 0.060.12 ± 0.040.01 ± 0.020.68 ± 0.260.24 ± 0.09The low-dose vaccine group0.74 ± 0.160.20 ± 0.031.78 ± 0.330.49 ± 0.073.61 ± 0.360.79 ± 0.061.66 ± 0.320.37 ± 0.080.10 ± 0.010.04 ± 0.010.71 ± 0.270.26 ± 0.11The high-dose vaccine group0.76 ± 0.240.21 ± 0.031.72 ± 0.550.48 ± 0.073.38 ± 0.370.74 ± 0.061.49 ± 0.190.33 ± 0.050.10 ± 0.020.04 ± 0.010.59 ± 0.210.22 ± 0.08GroupTest timeNumber of animalsBody weight (g)BrainHeartLiverKidneyAdrenalThymusAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weight(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)The negative control group14 days after the last administration10412.3 ± 115.32.11 ± 0.130.55 ± 0.141.34 ± 0.420.32 ± 0.0411.27 ± 3.082.75 ± 0.222.56 ± 0.700.63 ± 0.060.08 ± 0.020.02 ± 0.010.46 ± 0.140.11 ± 0.03The solvent control group396.3 ± 110.52.05 ± 0.180.55 ± 0.131.24 ± 0.350.31 ± 0.0411.66 ± 3.302.94 ± 0.182.56 ± 0.690.65 ± 0.050.07 ± 0.010.02 ± 0.010.46 ± 0.130.12 ± 0.04The low-dose vaccine group393.0 ± 122.62.09 ± 0.170.58 ± 0.161.32 ± 0.380.34 ± 0.0311.06 ± 2.962.86 ± 0.282.59 ± 0.780.66 ± 0.060.08 ± 0.020.02 ± 0.010.48 ± 0.100.13 ± 0.03The high-dose vaccine group404.0 ± 122.42.12 ± 0.100.57 ± 0.161.27 ± 0.300.32 ± 0.0512.44 ± 3.993.10 ± 0.392.64 ± 0.660.67 ± 0.080.08 ± 0.010.02 ± 0.010.56 ± 0.190.14 ± 0.03GroupTest timeNumber of animalsSpleenLungTestisEpididymisOvaryUterusAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weightAbsolute valueRelative weight(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)(g)(g/100 g)The negative control group14 days after the last administration100.74 ± 0.140.18 ± 0.031.84 ± 0.370.46 ± 0.073.48 ± 0.210.68 ± 0.061.66 ± 0.270.32 ± 0.060.14 ± 0.030.04 ± 0.010.80 ± 0.280.26 ± 0.10The solvent control group0.75 ± 0.240.19 ± 0.021.72 ± 0.390.44 ± 0.053.28 ± 0.280.66 ± 0.071.56 ± 0.230.31 ± 0.050.10 ± 0.020.03 ± 0.010.61 ± 0.110.21 ± 0.04The low-dose vaccine group0.75 ± 0.250.19 ± 0.021.74 ± 0.340.46 ± 0.093.64 ± 0.380.72 ± 0.031.51 ± 0.480.30 ± 0.110.10 ± 0.020.04 ± 0.010.77 ± 0.240.28 ± 0.08The high-dose vaccine group0.78 ± 0.260.19 ± 0.021.79 ± 0.470.45 ± 0.073.49 ± 0.330.69 ± 0.031.48 ± 0.300.29 ± 0.070.09 ± 0.020.03 ± 0.010.76 ± 0.180.26 ± 0.06
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